• Despite low respiratory rates in citrus fruit

  2020-05-25

  

  Despite low respiratory rates in citrus fruit, prolonged periods of storage may cause significant changes in the levels of organic acids (Echeverria and Valich, 1988). V-ATPase and V-PPase catalyze the electrogenic H+ translocation from the cytosol to the vacuolar lumen to generate an inside-acid pH

• DNA damage represents a persistent threat to genomic stabili

  2020-05-22

  

  DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS

• SNOG Analysis of Table shows that compound

  2020-05-22

  

  Analysis of Table 1 shows that compound 7b, in which the biphenyl scaffold does not bear any substituent, displays its inhibitory potency in the micromolar range (IC50 = 11 μM). If the amide bridge is moved from position 1 to 3 of the biphenyl system, product 7c is yielded, whose potency is about 4

• br Conclusions This study showed

  2020-05-22

  

  Conclusions This study showed that in EOC cells, tyrosine kinase receptor DDR1 was expressed mainly in EOC Cy5 EGFP with an Epithelial phenotype. The repressed expression of DDR1 in EOC cells with Mesenchymal phenotype could be due to the higher CpG methylation levels observed at the promoter of

• Significantly less is known about regulation

  2020-05-22

  

  Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t

• To further determine the cell death

  2020-05-22

  

  To further determine the cell death, the ochratoxin australia in flasks were harvested after OGD or LTD4 treatment, washed twice with PBS, and evaluated with Annexin V (AV)-FITC apoptosis detection kit I (BD Biosciences Pharmingen, USA) on a flow cytometer (FACSCalibur, Becton–Dickinson, USA). Brie

• The protein levels of the

  2020-05-22

  

  The protein levels of the three enzymes in the organs in the three earthworm species ranked body wall > intestine > seminal receptacle ≈ seminal vesicle (Fig. 3B).The presence of significant detoxification capability in the body wall would be logically expected in a soil dwelling organism, to facili

• VE821 br Acknowledgements We thank Jeffrey D Konowalchuk and

  2020-05-22

  

  Acknowledgements We thank Jeffrey D. Konowalchuk and John Sony Robbins for their technical assistance. This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) grants to DRB (RGPIN-2013-355303) and MB (RGPIN-2014-96395). AMR was supported by NSERC Vanier Doct

• CPG a metalloenzyme derived from

  2020-05-22

  

  CPG2, a metalloenzyme derived from sp., was the elected enzyme for the first pilot-scale clinical trial of ADEPT. This enzyme has no mammalian homologue and activates glutamic MK-2206 prodrug derivatives of several nitrogen mustards alkylating agents., , , , , A bond cleavable by CPG2 is essentia

• br Roles for intracellular chloride channels

  2020-05-22

  

  Roles for intracellular chloride channels Specific chloride channel proteins in intracellular membranes Concluding remarks Introduction The sulfonylurea derivative glybenclamide (GLYB) is used as oral hypoglycemic agent to treat non-insulin dependent diabetes mellitus [1], [2]. The antid

• LP a levels are lowered by

  2020-05-22

  

  LP(a) levels are lowered by combined oral hormone therapy [80], [81], [82], [83], [84], whereas for most studies using transdermal HRT little or no changes have been observed [85], [86], [87]. Oral versus transdermal administration In general most markers are influenced in a similar way by oral

• br Materials and methods br Results

  2020-05-22

  

  Materials and methods Results Discussion The effect of progestogen treatment showed some tendencies affecting the body length and weight, however these data were not verifiable statistically. This observation could be explained with the relatively short exposure period and/or the relatively

• br Conclusions br Acknowledgements Implantable Microsystems

  2020-05-22

  

  Conclusions Acknowledgements Implantable Microsystems for Personalised Anti-Cancer Therapy is a EPSRC (Engineering and Physical Sciences Research Council, UK) funded grant (Ref. EP/K034510/1) Introduction Flemingia philippinensis, belonging to the legume family, is a polyphenol rich plant

• br Introduction Plasmodium falciparum malaria continues to b

  2020-05-22

  

  Introduction Plasmodium falciparum malaria continues to be a major global cause of mortality and morbidity. Malaria treatment and control has been complicated by the emergence of resistance to widespread antimalarial drug use. The most common method for measuring antimalarial resistance is estima

• As a basis for the DDR substrate identification approach

  2020-05-22

  

  As a basis for the DDR1 substrate identification approach detailed below, we first set out to perform 2D-gel electrophoresis with lysates isolated from collagen-stimulated human breast cancer MDA-MB-231 3902 australia overexpressing DDR1 (b-isoform). This allowed us to determine whether DDR1 is not

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