• A recent study revealed that in human glioma

  2021-05-20

  

  A recent study revealed that in human glioma cells, DNA-PKcs interacted with the regulatory γ subunit of AMPK and positively regulated AMPK phosphorylation and activation under glucose-deprived conditions. This suggested that DNA-PK is an important regulator of AMPK activation in response to energy

• In all available E E

  2021-05-20

  

  In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans

• DA neurons are capable of

  2021-05-20

  

  DA neurons are capable of somatodendritic and axonal DA release, which may occur at synapses, as well as non-synaptic or asynaptic sites (Trudeau et al., 2014). DA may also be released at different timescales and in response to different DA neuron firing patterns (Grace et al., 2007). Furthermore, s

• br Introduction Addiction to opioids

  2021-05-20

  

  Introduction Addiction to opioids such as morphine is a chronic disorder that affects the mesocorticolimbic dopaminergic pathway in the brain. Activation of the pathway ultimately leads to dopamine release in the nucleus accumbens (NAc) (Di Chiara et al., 1998) and stimulation of dopamine recepto

• br Introduction In most of the angiosperms

  2021-05-20

  

  Introduction In most of the angiosperms, sexual reproduction requires a process called double fertilization where the specialized cell division called meiosis produces haploid gametes combine to form diploid (2n) embryo. In Thiola to this, apomixis, naturally occurs in at least 400 plant families

• br Conclusions br Conflict of interest br Financial disclosu

  2021-05-20

  

  Conclusions Conflict of interest Financial disclosure Introduction In prokaryotes, six distinct autotrophic CO2 fixation pathways have been identified so far. Of these pathways, 3-hydroxypropionate/4-hydroxybutyrate (3-HP/4-HB) cycle is one of the recently discovered pathways [1]. The 3-

• Interaction between neutrophils and ECs represents the first

  2021-05-19

  

  Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that

• br Material and methods br

  2021-05-19

  

  Material and methods Results Discussion Conclusions To conclude, although CPT2 and CPT1 must have co-evolved to establish the carnitine shuttling, these enzymes are the most distantly related carnitine transferases, split early in evolution, during which a switch occurred in their locati

• possible The instructive precedent for galectin phosphorylat

  2021-05-19

  

  The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T

• Although it remains an unsettled issue evidence favors that

  2021-05-19

  

  Although it remains an unsettled issue, evidence favors that the endothelin ETA Amiloride HCl dihydrate sale may play a more important pathological role. While both endothelin ETA and ETB receptors are found in most tissues, endothelin ETA receptor is the predominant receptor responsible for the vas

• In the brain E can modulate the mitogen activated

  2021-05-19

  

  In the brain, E2 can modulate the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway, which is involved in the formation of different memory types (Atkins et al., 1998, Blum et al., 1999, Schafe et al., 2000). When the MAPK/ERK signaling pathway is activated,

• We recently employed a functional drug screening

  2021-05-19

  

  We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito

• The T cell receptor TCR pathway is associated with

  2021-05-19

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• Biotin-HPDP In addition to tissue resident stromal and

  2021-05-19

  

  In addition to tissue-resident stromal and myeloid cell populations, ILCs also readily engage in positive-feedback loops with myeloid Biotin-HPDP recruited from the circulation. TNF-α produced by inflammatory monocytes recruited to the lungs of mice infected with Klebsiella pneumoniae markedly incre

• The importance of EBI for B cell

  2021-05-19

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed B cells and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvement of EBI2 in

14654 records 576/977 page Previous Next First page 上5页 576577578579580 下5页 Last page