• br Mechanisms of action Ghrelin

  2021-12-15

  

  Mechanisms of action Ghrelin is a 28-amino Cy5 carboxylic acid (non-sulfonated) peptide hormone primarily produced in the oxyntic mucosa of stomach, but also in other gastrointestinal tissues [7] (Fig. 1). It acts as the endogenous ligand for the ghrelin receptor [GHS-R1a] and causes the release

• Nano biocatalyst prepared by assembling

  2021-12-15

  

  Nano-biocatalyst, prepared by assembling an enzyme on nanomaterial (NM) carriers is an emerging innovation in the field of nanobiotechnology. Some of the advantages of using NM as supports in LY3009120 australia to conventional porous supports are effective enzyme loading due to large surface area

• br Acknowledgement This work was supported by National Scien

  2021-12-15

  

  Acknowledgement This work was supported by National Science Foundation (21475047, 21705051, 21874048), the Science and Technology Planning Project of Guangdong Province (2016B030303010), the Program for the Top Young Innovative Talents of Guangdong Province (2016TQ03N305) and the Foundation for H

• Here we investigated on epigenetic regulatory mechanisms of

  2021-12-14

  

  Here, we investigated on epigenetic regulatory mechanisms of ALX/FPR2 expression. Epigenetic changes, that include phosphorylation, acetylation, methylation and ubiquitination of DNA and histone proteins, occur in a variety of diseases [21] and are being recognized as key targets for personalized me

• br Author contributions br Acknowledgements

  2021-12-14

  

  Author contributions Acknowledgements The work was supported in part by Natural Science Foundation of China (31601995, 31501028) and an internal research grant of Jianghan University (14042). The authors thank HY of Jingchu University of technology for revising the manuscript. Introduction

• In normal tissues the expression patterns of GPR

  2021-12-14

  

  In normal tissues, the expression patterns of GPR120 and GPR40 are not uniform. GPR120 is highly expressed in adipocytes, lung and intestinal tract, while GPR40 is shown to be expressed in pancreatic islet TG4-155 and intestinal tract [7], [20]. It is considered that the distribution of the GPR120

• Milligan et al demonstrated the important role of

  2021-12-14

  

  Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr

• Hepatic drug metabolizing enzymes and

  2021-12-14

  

  Hepatic drug-metabolizing Retigabine dihydrochloride and transporters expression were regulated by nuclear receptors [19], [20], [21]. The effects of HFD-induced fatty liver on drug metabolizing enzymes in mice were recently studied, and the results provided a systematic evaluation of the changes of

• Ning et al showed that

  2021-12-14

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• In glioma or glial derived primary brain tumors as

  2021-12-14

  

  In glioma, or glial-derived primary ly411575 receptor tumors, as in other cancers, glutathione is an important survival mechanism. Glioma cells are dependent upon SXC-mediated cystine uptake for viability, as they require intracellular cystine/cysteine for GSH synthesis (Ogunrinu and Sontheimer, 20

• The discovery that GLUT in the microvasculature

  2021-12-14

  

  The discovery that GLUT1 in the microvasculature represents an important target of VEGF thereby affecting endothelin receptor antagonists function is highly relevant. The work of Jais et al. identified VEGF as a determining player in the regulation of cognitive performance and provides an important

• Introduction Human pathogenic Leishmania protozoa comprise d

  2021-12-14

  

  Introduction Human pathogenic Leishmania protozoa comprise 20 different species that are distributed throughout the world and cause the disease leishmaniasis [1]. Transmission primarily occurs through the bite of a female sand fly and clinical manifestations of the disease span from cutaneous lesio

• The most classic case of acquired

  2021-12-14

  

  The most classic case of acquired and relapsing epilepsy is temporal lobe epilepsy (TLE), which originates from the hippocampal formation, a structure situated in the mesial temporal lobe (Majores et al., 2007). Our experiment used the prominent pilocarpine-induced TLE model. Systemic administration

• br Conflicts of interest br Acknowledgments This

  2021-12-14

  

  Conflicts of interest Acknowledgments This work was supported by the following funds: National Natural Science Foundation of China (81502222); Natural Science Foundation of Hubei Province (2013CFB370); Training program for Wuhan young and middle-aged medical backbone personnel (2017–51). In

• Zn is the second most abundant

  2021-12-14

  

  Zn2+ is the second most abundant trace metal in many cells and neurons in the brain. It regulates cellular functions such as gene expression, epigenetic enzymatic activity, protein structural stability, and neuronal plasticity. Zn2+ is particularly abundant in the cortex and limbic system, including

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