• br The complementary role of chaperone mediated

  2025-02-01

  

  The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa

• In our studies of leucine and BCH in

  2025-02-01

  

  In our studies of leucine and BCH in pancreatic islets and clonal insulin cell lines, we noticed that leucine was a slightly stronger stimulant of insulin release. Previous studies showed that leucine can be metabolized to CO2[11], [12], [13], [14] and can increase acetoacetate in pancreatic islets

• gsk525762 Despite these conflicting data about COX

  2025-01-31

  

  Despite these conflicting data about COX-2/ER correlations, a large body of evidence supports that elevated COX-2 expression in breast cancer is a constant feature of high stage disease and a predictor of worse outcome. Upregulation of COX-2 protein has been identified in approximately 40% of cases

• Introduction Induction of long term potentiation LTP the

  2025-01-31

  

  Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int

• br Alzheimer s disease AD is an irreversible

  2025-01-31

  

  Alzheimer’s disease (AD) is an irreversible, age-associated neurodegenerative disorder that is characterized by progressive memory loss and cognitive decline. AD is also the leading cause of dementia, accounting for 5 million cases in the United States and 44 million cases worldwide. In 2015, AD c

• The present study indicates elevated ATX activity as a highl

  2025-01-27

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In Gemcitabine to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a

• br Methods br Results br Discussion

  2025-01-27

  

  Methods Results Discussion Autotaxin has been shown to have effects on major cell types implicated in OA, notably chondrocytes, osteoblasts, osteoclasts, and synoviocytes, through its enzymatic product LPA [20]. However, a paucity of research exists on the involvement of autotaxin in OA. Fi

• In Rainey et al published the results of

  2025-01-27

  

  In 2008, Rainey et al. published the results of a targeted compound library screen for potential inhibitors of the ATM kinase. In this study, the compound CP466722 was identified as a highly selective and rapidly reversible ATM inhibitor, which did not inhibit PI3K or related PIKK family members. Mo

• br Materials and methods br Results br Discussion

  2025-01-27

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino Endocannabinoid system modulator sequence identity among these species is not high (38–52%), our synte

• In Pham et al employed the microsphere based technology

  2025-01-27

  

  In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi

• br AR mediated actions in cells of the vascular wall

  2025-01-27

  

  AR-mediated actions in np e of the vascular wall Sex hormones may influence the size and composition of atherosclerotic lesions indirectly by modifying systemic cardiovascular risk factors such as plasma lipids profiles and insulin sensitivity; this aspect of their action is discussed elsewhere

• The advantage of active immunotherapy is long term antibody

  2025-01-27

  

  The advantage of active immunotherapy is long-term antibody production from short-term drug administration at limited cost. Conversely, immune response may be inconsistent or lacking, especially in older individuals, and adverse reactions—if immunologically based—may also be long-lasting. Initial ex

• The importance of TARPs for

  2025-01-27

  

  The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule Bradykinin acetate synthesis (C

• br Experimental br Acknowledgment br

  2025-01-26

  

  Experimental Acknowledgment Introduction The NADPH-dependent reduction of d-glucose catalyzed by aldose reductase (E.C.1.1.1.21) (AR) is considered as one of the phenomena leading to the onset of long term diabetic complications [as review see: [1], [2]. In fact, the reduction of the sugar,

• Gratifyingly compound also demonstrated improved physicochem

  2025-01-26

  

  Gratifyingly, compound also demonstrated improved physicochemical properties with significant improvement in aqueous solubility. Compound was sufficiently potent to determine its pharmacokinetic (PK) and pharmacodynamics (PD); data is summarized in . shows ADME characteristics for compound and as

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