• A disfun o cognitiva p s operat ria uma s

  2024-07-24

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma sphingosine-1-phosphate disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questã

• While the mechanisms by which

  2024-07-24

  

  While the mechanisms by which ALDH2 regulates cardiac responses to pathological stress remain unclear, the capillary rarefaction found in pressure-overloaded ALDH2 Tg hearts provides potential clues. Loss of capillary density and diminished endothelial function occur in pathological hypertrophy [46]

• There are some limitations and further experiments

  2024-07-24

  

  There are some limitations and further experiments that are required. First, to our surprise, measurement of the cardiomyocyte cross-sectional area in Akt1−/−/iAkt2 KO mice showed comparable areas to WT mouse despite of reduced heart weight. In addition to measuring cardiomyocyte cross-sectional are

• Growing evidence indicates that GRKs can exert different

  2024-07-24

  

  Growing evidence indicates that GRKs can exert different effects within the cell depending on the stimulus, cell type, and localization [97], [121]. In this sense, we were the first to demonstrate a mitochondrial localization for GRK2 [122], later confirmed by other investigators [123], establishing

• br Hypothesis The hypothesis is that

  2024-07-24

  

  Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un

• Human testicular peritubular cells HTPCs are also

  2024-07-24

  

  Human testicular peritubular Ceftazidime (HTPCs) are also the only human testicular cell type that can be isolated, cultured and studied in vitro (Albrecht et al., 2006, Mayerhofer, 2013). Results from recent studies indicate that their roles go beyond sperm transport and include immunological func

• In the past years the role of

  2024-07-24

  

  In the past 10 years, the role of the CD73-adenosinergic pathway in suppression of anti-tumor immunity has increasingly been recognized [13], [14]. In this review, we discuss the latest findings dealing with the regulation of anti-tumor immunity by CD73 and adenosine. We also discuss ongoing clinica

• As an alternative to chronic

  2024-07-24

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify iCRT 14 adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitates th

• br Results br Discussion To achieve quantitative

  2024-07-24

  

  Results Discussion To achieve quantitative understanding of parp inhibitor turnover, we utilize rapidly moving lamellipodial fragments that are geometrically simple, structurally homogeneous, and persistent, and measure relevant rates and concentrations in this system. We find that the lamell

• br Patients and Methods br Results br Discussion Gjerdrum et

  2024-07-24

  

  Patients and Methods Results Discussion Gjerdrum et al showed that Axl Methimazole is required to maintain the mesenchymal-like invasiveness of metastatic breast carcinoma cells, but Axl knockdown has no effect on the cell proliferation of MDA-MB-231 cells. Mackiewicz et al also showed that

• In conclusion we have designed

  2024-07-24

  

  In conclusion, we have designed and synthesized a series of 4-phenyl-thiazole analogues as potent ATX inhibitors. Total twenty-five compounds were synthesized and evaluated for their inhibitory activity on ATX using FS-3 and human plasma assays. Compound was found to be the most potent derivative p

• br Introduction Stroke is a devastating

  2024-07-24

  

  Introduction Stroke is a devastating condition that causes cognitive and motor dysfunction, neurodegenerative diseases and even acute death, and is a leading cause of mortality and morbidity worldwide (Chen et al., 2014a, Wang et al., 2016). Thus, exploration or identification of novel therapeuti

• 1 98 In liver the essential organ of lipoprotein synthesis A

  2024-07-24

  

  In liver, the essential organ of lipoprotein synthesis, ACL plays a fundamental role in lipogenesis and steroidogenesis by supplying cytosolic 1 98 to both pathways. By using a tricarboxylic acid cycle intermediate (citrate) to produce acetyl CoA, ACL can be seen as an important bridge between carbo

• sodium butyrate australia IGF signaling has been shown to in

  2024-07-24

  

  IGF-1 signaling has been shown to induce sodium butyrate australia changes via interacting with MKK-p38 signaling (Serra et al., 2007) and by perturbing Foxo3a signaling (Stitt et al., 2004), among other mechanisms. The current study demonstrates that the acetyl group itself may be limiting, since

• br Materials and Methods br Results br

  2024-07-24

  

  Materials and Methods Results Discussion 15-HETE is a predominant eicosanoid in pulmonary vascular remodeling, and it could promote hypoxia-induced PAH via its involvement in the regulation of proliferation and cell cycle progression in PASMCs. To understand its role in HPH, we have previou

15294 records 108/1020 page Previous Next First page 上5页 106107108109110 下5页 Last page