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Neutrophils produce high amounts of
2020-01-22
Neutrophils produce high amounts of ROS, which act as antimicrobial agents, signaling molecules or initiators during PMA-induced NET formation. Of the intravenous anesthetics used in this study, propofol was the best at decreasing PMA-induced ROS levels (Fig. 3A and B). Our previous study also demon
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Intriguingly one E residue may serve as
2020-01-22
Intriguingly, one E2 residue may serve as a molecular ‘gate’ to allow the C-terminus of ubiquitin to access the closed E2~Ub conformations favorable for ubiquitin transfer. This residue, Asp87 in UbcH5 family members, resides on one side of the opening that leads to the active site Cys (Fig. 4D). In
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br Materials and Methods br Acknowledgements Authors would
2020-01-22
Materials and Methods Acknowledgements Authors would like to thank Mr. Pritam Naskar and Mr. Dibya Mukherjee for their help. Authors also acknowledge the help of Mr. Barun Mahata and Dr. Kaushik Biswas, Division of Molecular Medicine, Bose Institute, for human cDNA samples. P.A.B. and A.B.D. w
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Cytochalasin J Regarding the mechanism of action of
2020-01-21
Regarding the mechanism of action of CRF, several studies have shown that low doses of CRF may preferentially activate CRF1 receptors in glutamatergic projection neurons, serotoninergic neurons or glutamatergic collaterals in the medial prefrontal cortex (Vertes, 2004). Indeed, prosencephalic inacti
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br Acknowledgements This work was supported by the European
2020-01-21
Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360. We are grateful to Dr. T.T. Hoang for the provision of plasmids pEX18Tc, pPS858 and pFLP2, Prof. B.L. Wanner for providing us with the plasmid pKD4 and related strains, and Prof. P. Soucail
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Form the previous literature It was observed that RHA was
2020-01-21
Form the previous literature, It was observed that RHA was burnt in the range of 500 °C to 700 °C, with high content of quartzite silica was used is a partial replacement of cement in mortar and in concrete. The results shown an excellent behavior in enhancing the mechanical properties of cement mor
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Little information is available regarding the
2020-01-21
Little information is available regarding the expression of the different EP receptor subtypes on human monocytic cells, particularly those that are involved in downregulating cytokine production. The receptors are controlled by the respective genes for each receptor i.e. PTGER1–PTGER4 for EP1–EP4 r
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br Conclusion br Acknowledgments This work
2020-01-21
Conclusion Acknowledgments This work was supported by Progetto PON - “Ricerca e Competitività 2007–2013” - PON01_01802: “Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redox-sensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e lor
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As the angular structure of compound
2020-01-21
As the angular structure of compound cannot be differentiated from the linear structure by H NMR spectroscopy, a NOESY NMR experiment was performed to unambiguously characterize the regioselectivity of the final compound. In the linear compound , a signature correlation between the proton of the t
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Studies have shown that endothelial cells damaged by
2020-01-21
Studies have shown that endothelial cells damaged by SAH can release a large amount of ET-1, thus its plasma level is elevated and is positively correlated with the symptoms of SAH (Lei et al., 2015, Masaoka et al., 1989). Our data obtained from SAH-along rabbits were consistent with these findings.
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br Materials and methods br Results br Discussion DDR played
2020-01-21
Materials and methods Results Discussion DDR2 played a role in cell motile behavior, but the relationship between motility and collagen activation of DDR2 tyrosine kinase was unclear. Studies with smooth muscle cells from DDR1−/− mice demonstrated a defect in cell attachment to collagen and
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DDR expression is upregulated in
2020-01-21
DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident vasopressin receptor antagonists is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting a pro-fibro
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Studies of LRRK tagged with green fluorescent protein reveal
2020-01-21
Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the Mercaptopurine australia of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 def
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br Materials and methods br Results br Discussion CDK and
2020-01-21
Materials and methods Results Discussion CDK and their regulatory cyclins form a family of heterodimeric kinases that are particularly important for regulation of erk pathway progression and transcription in tumor cells. These kinases therefore constitute biomarkers of proliferation and att
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As we all known hypoxia is a hallmark of
2020-01-21
As we all known, hypoxia is a hallmark of tumour microenvironment, which is a key regulator of tumour growth and metastasis [4]. Hypoxia meditates a series of cellular responses including angiogenesis by activating transcriptional factor hypoxia inducible factor (HIF), which is consist of an obligat
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