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The death associated protein kinase DAPK is an actin
2020-11-25
The death-associated protein kinase (DAPK) is an actin-associated, calcium/calmodulin-dependent enzyme with serine/threonine kinase activity [11], [12]. DAPK is a pro-apoptotic gene and participates in various apoptotic systems, such as TNF-α- and Fas-triggered apoptosis [10], IFN-γ-induced cell dea
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Some studies have demonstrated that BMSCs can
2020-11-25
Some studies have demonstrated that BMSCs can provide several trophic and growth factors that play important roles in cell survival, angiogenesis, and BMSC differentiation, but not cell replacement (Peled et al., 1999, Shen et al., 2007, Ji et al., 2004). This paracrine effect of BMSCs is a potentia
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br Materials and methods br Results br Discussion
2020-11-25
Materials and methods Results Discussion We confirmed the published cDNA and protein sequence of feline CSF-1R and stably cloned the cat receptor into the Ba/F3 cell line. Activation of feline CSF-1R by recombinant human CSF-1 was previously tested by Woolford et al. [14]. Expression of onc
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br Next let s recall some
2020-11-24
Next, let's recall some definitions and notations from [14] which are necessary to obtain the proof of Theorem 1. Let denote the CMV matrix whose Verblunsky coefficients replaced by , that is The corresponding extended CMV matrix is Recall the definition of in the proof of Theorem 2, replace
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Two nutrient sensing pathways the
2020-11-24
Two nutrient-sensing pathways, the cAMP-protein kinase A (PKA) pathway and the target of rapamycin complex 1 (TORC1) pathway, are implicated in Msn2/4 regulation. Under non-stress conditions, Msn2 localizes in the cytoplasm and is inactivated by both PKA-dependent phosphorylation of the nuclear loca
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br Disclaimer Statement br Introduction The erythropoietin p
2020-11-24
Disclaimer Statement Introduction The erythropoietin-producing hepatoma (Eph) receptors represent the largest class of receptor tyrosine kinases (RTKs). They are type I transmembrane proteins that interact with their membrane-bound ligands the ephrins and facilitate cell-to-cell contacts resul
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br Cytochrome P monooxygenases Cytochrome P monooxygenases
2020-11-24
Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o
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The ultrafiltration approach has been used to measure
2020-11-24
The ultrafiltration approach has been used to measure equilibrium BIEs for a number of enzyme systems, including Gemcitabine hexokinase (Lewis and Schramm, 2003a, Lewis and Schramm, 2003b), thymidine phosphorylase (Birck & Schramm, 2004), purine nucleoside phosphorylase (Murkin, Tyler, & Schramm, 20
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all trans retinoic acid Ultrasound is an acoustic wave with
2020-11-24
Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of
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OxLDL down regulates eNOS and up
2020-11-24
OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial Telenzepine dihydrochloride receptor [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For
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Celiac disease occurs in the small intestine due to
2020-11-24
Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they
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In principle in vitro techniques for assessing enzyme induct
2020-11-24
In principle, in vitro techniques for assessing enzyme induction might include the use of cultured hepatocytes, precision-cut liver slices, immortalized R 59-022 lines (such as those derived from hepatomas) and reporter gene constructs (where appropriate cells are transfected with recombinant DNA en
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W146 mg The molecular mechanisms regulating the differentiat
2020-11-24
The molecular mechanisms regulating the differentiation of Th1 versus Tfh W146 mg from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation promotes mouse naive CD4+ T cells to express bot
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Most of the data indicating that
2020-11-24
Most of the data indicating that the six-ankyrin repeat domain-containing Asb genes drive compartment expansion come from zebrafish and concern Asb11. However, there is evidence to suggest that these data can be expanded to the entire vertebrate phylum and to all six-ankyrin repeat domain-containing
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methylergometrine Contrary to the profuse dopaminergic inner
2020-11-23
Contrary to the profuse dopaminergic innervation of the thalamus found in human and non-human primates (Brown et al., 1979, Sanchez-Gonzalez et al., 2005), in rodents, the RTn is one the few thalamic nuclei that receives dopaminergic input (Anaya-Martinez et al., 2006, Garcia-Cabezas et al., 2007, G
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