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br Discussion Estradiol is known as
2020-11-27
Discussion Estradiol is known as one of the stress signaling molecule [3,4,14]. Here, we showed that PH induced estradiol production before hepatocyte proliferation (Fig. 1). Conversely, the ovariectomized and orchitectomized mice produced less estradiol after PH, and had delayed liver regenerati
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Synthesis of and is described
2020-11-27
Synthesis of 5–7, 12–14, and 18 is described in Scheme 3. Compounds 5–7 and 18 were prepared as outlined in Scheme 3a. Reaction of 4-bromomethylbenzoic saquinavir (36) with thionyl chloride yielded the corresponding acid chloride, which was converted to the corresponding amide 40a by the usual ammo
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br Materials and methods br Results
2020-11-27
Materials and methods Results Discussion Endothelial cells are crucial for both vascular homeostasis and protecting the vasculature against atherogenic insults [3]. OxLDL-mediated injury to endothelial cells is crucial for endothelial dysfunction in the pathogenesis of atherosclerosis and a
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br Funding br Disclosure of
2020-11-27
Funding Disclosure of interest Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic disease characterized by extensive deposits of the extracellular matrix (ECM) that can impair the architecture and function of the lungs (Cavazza et al., 2010). Imbalance between the prolifer
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In addition to grouping cases of B
2020-11-27
In addition to grouping cases of B-ALL by cell of origin, these lymphomas can also be subcharacterized by genetic rearrangements. Fusion of the purinergic receptor P2RY8 promoter to the CRLF2 (cytokine receptor like factor 2) gene frequently occurs in B-ALL but reports of the functional consequences
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The two most important biological machineries controlling pr
2020-11-27
The two most important biological machineries controlling proteostasis, PQC, and degradation are autophagy and the ubiquitin-proteasome system (UPS) (). Autophagy is a lysosome-dependent, tightly regulated catabolic process that degrades unwanted cell organelles and cytoplasmic constituents in lysos
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br Materials and methods br Results br Discussion Natural co
2020-11-27
Materials and methods Results Discussion Natural compounds and their derivatives have been investigated as candidates for the treatment of bone diseases and can also be the sources of nutraceutical agents and therapeutic agents [28]. Using peptides as therapeutic effects on bone-related dis
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bafilomycin a1 autophagy br Materials and methods br Results
2020-11-27
Materials and methods Results Discussion The 5-HT2A and D2 receptors have a functional crosstalk (Albizu et al., 2011) and they bafilomycin a1 autophagy are all richly expressed in the mesolimbic and mesocortical systems (Azmitia and Segal, 1978; McMahon et al., 2001), providing the neuroan
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Our finding that one enzyme
2020-11-27
Our finding that one enzyme acts both as a primase and a DNAP poses evolutionary and mechanistic questions. In particular, why do cellular organisms require two enzymes to fulfill de novo DNA synthesis? The inability of cellular replicases to perform as primases might be dictated by the challenges a
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The members in apple are similar in number to
2020-11-27
The 8 members in apple are similar in number to the 7 in Arabidopsis and the 8 in rice, but fewer than the 10 found in mammalian species. GenBank numbers have also been reported for DGK homologues from tomato (AW035995), maize (AY106320), wheat (BT009326), a Populus cross (BU828590), grape (CB981130
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CDK lacks DNA binding domains and nuclear localization
2020-11-26
CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX
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Fear like behaviors are produced by intracerebroventricular
2020-11-26
Fear-like behaviors are produced by intracerebroventricular CRF administration (Meloni et al., 2006, Radulovic et al., 1999), as well its administration into specific Cyanine 5-dCTP areas such as the amygdala (Daniels et al., 2004, Donatti and Leite-Panissi, 2011), the periaqueductal gray matter (Ma
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In contrast to PEGylated proteins which tend to have reduced
2020-11-26
In contrast to PEGylated proteins which tend to have reduced N-Nonyldeoxynojirimycin in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the
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Introduction The carnitine choline acyltransferase family is
2020-11-26
Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) zingerone and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of seve
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often line up to buy br Materials and methods br Results br
2020-11-26
Materials and methods Results Discussion In our tissue array, we demonstrated that 14-3-3 tau mRNA and protein expression levels decreased in the preeclamptic placentas. 14-3-3 proteins are considered to be important in the functional regulation of trophoblasts and maybe associated with adv
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