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idarubicin receptor Similarly in the EAE model Chalmin et
2021-03-16
Similarly in the EAE model, Chalmin et al. previously demonstrated that EBI2 and CH25H might be responsible for the efficient egress of differentiated Th17 cells from the draining lymph nodes [31]. As discussed above, in active EAE we did not find differences in EAE development and only the transfer
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br Asb Proteins and Mitochondrial Function Mitochondria
2021-03-16
Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic Altretamine and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate a plethora of pro
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A-71623 mg Among the Ub interactions observed
2021-03-16
Among the ~Ub interactions observed in the HOIP structure is one that involves a RING2 domain (from the non-cognate HOIP) [47]. A similar binding interaction was defined between HHARI RING2 and the hydrophobic patch on Ub by NMR [54]. HHARI RING2 mutations that ablate the interaction inhibit formati
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br STAR Methods br Author Contributions br Acknowledgments
2021-03-16
STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer
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We have previously reported DAPK inhibitors
2021-03-16
We have previously reported DAPK inhibitors discovered through our structure-based virtual screening (SBVS) research program. In this paper, we describe the general protocol of our in silico approach, and the strategy used to develop hit compounds. In addition, the studies conducted on the structure
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The purposes of this study is
2021-03-16
The purposes of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs using S-hexyl GSH, and to clarify the mechanism underlying response to such trapping using montelukast, a CysLT1 receptor antagonist, BayCysLT2RA, a CysLT2 recepto
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Angiotensin 1/2 (1-9) The different diagnostic outcomes of t
2021-03-15
The different diagnostic outcomes of the two assays are also dependent on the used stimuli. The QuantiFERON-CMV assay targets CD8 + T Angiotensin 1/2 (1-9) by using peptides whereas the T-Track-CMV targets CD4+ and CD8 + T cells by stimulation with two viral proteins [18]. In our study, a specific
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br Conclusion and future perspectives LDL cholesterol loweri
2021-03-15
Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol dopamine receptor the efficacy of cholesterol lowering, both, with statins and with eze
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br Loss of Chk sensitizes cells to hypoxia
2021-03-15
Loss of Chk 1 sensitizes ml to moles to hypoxia/reoxygenation In contrast to Chk 2, studies have identified Chk 1 as being phosphorylated in an ATR-dependent manner at residue serine 345 during hypoxia [18]. More recently, siRNA mediated inhibition of Chk 1 signaling was found to sensitize cells
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In silico modelling studies might aid our understanding
2021-03-15
In silico modelling studies might aid our understanding of the functionality and potential biological activity of food and, in the long-term they might underpin the development of personalised diets to reduce health risks and help us to better understand pharmaceutical/food interactions. Acknowle
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ERR is constitutively active in the absence of endogenous
2021-03-15
ERRγ is constitutively active in the absence of endogenous ligand. However, several synthetic ligands that can repress or induce ERRγ function by disrupting ERRγ-coactivator interactions have been reported to date. The estrogen receptor modulators diethylstilbestrol (DES) and 4-hydroxytamoxifen (4-O
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In the present study promoting
2021-03-15
In the present study, promoting bile 69 7 mg synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis. This finding may be relevant for treatment of non-alcoholic fatty liver disease, a major cause of liver disease and prominent indication for liver transplantat
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Structure similarity searches were conducted using the
2021-03-15
Structure similarity searches were conducted using the standalone version of the DALI program with the query structures scanned against a local current version of the PDB that has all chains as separate entries (Holm and Sander, 1995). The structural hits for each query were collected, even if the D
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br Effect of DPP Inhibitors on the Clinical
2021-03-15
Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom
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The inhibition of NPY cleavage may also contribute to
2021-03-15
The inhibition of NPY cleavage may also contribute to the effect of gliptins on blood pressure [123]: NPY is an agonist of Y1 receptor mediating peripheral vasoconstriction. Interestingly, blood pressure in adult SHRs was not affected by single dose administration of a specific DPP-4i whereas blood
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