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Previous investigations have established that aromatase acti
2024-06-27
Previous investigations have established that aromatase activity is regulated via two different pathways in a tissue-specific manner. The first is a slower transcription regulatory pathway that involves an alteration in gene transcription and represents what is classically thought of as the way by w
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In addition understanding the relationship between human
2024-06-27
In addition, understanding the relationship between human metabolic processes and dietary antioxidant intake would provide opportunities for altering the diet to improve health (Prior, 2015). Prior et al. (2007) emphasized that excess reactive oxygen species, which occurred during the metabolism of
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Our surprising results show that AAD treated tumors adjacent
2024-06-27
Our surprising results show that AAD-treated tumors adjacent to adipose tissues and in steatotic liver continue to grow in the presence of a minimal number of microvessels. In non-adipose tumor models, the similar degree of vascular suppression is translated into marked suppression of tumor growth.
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The primary structure of the A peptide
2024-06-27
The primary structure of the Aβ peptide can be divided into four regions based on hydrophobicity. The N-terminal residues 1–16 comprise the first hydrophilic region, which also contains the metal binding site. More specifically, side chain carboxylate of D1 and the side chain nitrogens of H6, H13 an
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It has been reported that trehalose shows beneficial
2024-06-27
It has been reported that trehalose shows beneficial effects in a mouse model of several neurodegenerative diseases [21], [22], [23]. There are also reports showing that trehalose can improve the impaired cognitive and learning ability and reduced Aβ deposit in hippocampus of APP/PS1 transgenic mice
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br Disclosure br Acknowledgments br Introduction
2024-06-27
Disclosure Acknowledgments Introduction Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, belongs to the insulin receptor kinase subfamily [1]. Oncogenic activation of ALK is associated with the Neurotensin receptor and progression of multiple human cancer types [2,3], includin
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Further examination of these vmat IR cells shows
2024-06-27
Further examination of these vmat-IR cells shows that they are also positive for vimentin (vim-IR) (Fig. 3A). However, within any one cell there may be a region of weaker vmat-IR, suggesting sub-cellular localization. As also shown in Fig. 3B and C not all vim-IR cells are vmat-IR suggesting that th
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The theoretical calculations of ADME parameters
2024-06-26
The theoretical calculations of ADME parameters (molecular weight (MW), log P, topological polar surface are (tPSA), number of hydrogen donors (nON) and acceptors (nOHNH), and volume) and DLS are presented in along with the violations of Lipinski’s rule. According to these data, all compounds (–) c
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Matsuzaki et al attempted fertility therapy in
2024-06-26
Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a kanamycin heterozygote for delF53/54 and the missense mutation H373L, which has resulted. In addition to searching PubMed for reports on fertility in individuals with 17OHD, electroni
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We demonstrate a role for low oxygen to
2024-06-26
We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 Leupeptin and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA level
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br Viral manipulation of host factors to
2024-06-26
Viral manipulation of host factors to oppose anti-viral autophagy To escape or manipulate autophagy, some viruses developed strategies that are based on the recruitment of host-cell endogenous factors. The non-enveloped double-stranded DNA virus adenovirus is rapidly endocytosed after attachment.
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exemplifies three of the compounds investigated in
2024-06-26
exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC RO5185426 as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products.
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ASK belongs to the family of
2024-06-26
ASK1 belongs to the family of MAPKKK. ASK1-mediated apoptosis is involved in the pathogenesis of several diseases such as I/R injury, infectious diseases and neurodegenerative disorders [33], [34], [35]. ASK1 can be activated through different mechanisms. One mechanism is that oxidative stress direc
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Calcineurin has been established to be a ubiquitous Ca
2024-06-26
Calcineurin has been established to be a ubiquitous Ca2+-activated serine phosphatase in the nervous system (Pyrzynska et al., 2001). It has been reported that the activation of calcineurin protects aromatase from autophagy-mediated protein degradation, implying that calcineurin-dependent dephosphor
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JIB-04 By contrast with a plenty of our
2024-06-26
By JIB-04 with a plenty of our understanding on arginine metabolism in animals and higher plants, very little thus far is known on the specific function of arginase that acts as a key control point for keeping arginine balance in edible mushrooms and neither for its physiological role in postharves
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