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To further implicate the role of EAAT
2021-09-30
To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 KPT-335 australia was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-type
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Serotonin hydroxytryptamine HT is a monoamine with dual
2021-09-30
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine with dual functions in the developing and matured brain. 5-HT regulates development of the ochratoxin as a neurotrophic factor and is involved in emotion and cognition as a neurotransmitter in adulthood (Gaspar et al., 2003; Daubert and Condron, 2
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Prion diseases are transmissible and result
2021-09-29
Prion diseases are transmissible and result in fatal neurodegenerative disorders, which, similar to AD, also involve the infiltration and activation of mononuclear phagocytes in SB 225002 lesions (reviewed in [61]). A 21 amino-acid fragment of the aberrant human prion protein, Prp106–126, can form
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br Acknowledgments We apologize to the
2021-09-29
Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu
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EZH interaction with HADC and
2021-09-29
EZH2 interaction with HADC1 and HDAC2 through the EED subunit is known to recruit histone deacetylases [113,114]. Given that PRC2-mediated repression of transcription may be partly dependent on the function of HDACs in specific cell contexts [115], the leukemia cell treatment with hydroxamic E7080
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br Hippo Signaling in Autoimmunity
2021-09-29
Hippo Signaling in Autoimmunity An imbalance of T cell subsets, such as immunosuppressive regulatory T dizocilpine (Treg) and inflammatory TH17, has a key role in autoimmune diseases. Recently, investigations found that TAZ but not YAP enhances TH17 differentiation but attenuates Treg differentia
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It is acknowledged that mitochondrial outer
2021-09-29
It is acknowledged that mitochondrial outer membrane permeabilisation is a pivotal signal for apoptosis, which leads to the liberation of pro-apoptotic molecule such as cytochrome c and post-caspase activation [37]. As a consequence of the protection of mitochondrial integrity, AIV improved mitochon
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br Introduction Circulating tumor cells CTCs are
2021-09-29
Introduction Circulating tumor Chlorpropamide (CTCs) are cancer cells that have invaded blood vessels or lymphatics and are carried around the body by the blood. CTCs constitute potential seeds for metastasis because they can reach and implant into distant organs. The clinical importance of CTCs
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br Introduction Circulating tumor cells CTCs are
2021-09-29
Introduction Circulating tumor WIKI4 (CTCs) are cancer cells that have invaded blood vessels or lymphatics and are carried around the body by the blood. CTCs constitute potential seeds for metastasis because they can reach and implant into distant organs. The clinical importance of CTCs was highl
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br Acknowledgments br Introduction Histone deacetylases HDAC
2021-09-29
Acknowledgments Introduction Histone deacetylases (HDACs) related to tumor suppressor genes have become promising targets for the treatment of cancer [1,2]. Under the normal physiological conditions, Histone acetyltransferases (HATs) and histone deacetylases (HDACs) together regulate the acety
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Interestingly systemic circulating levels of NOx were not dr
2021-09-29
Interestingly, systemic circulating levels of NOx were not dramatically increased by treatment with isosorbide mononitrate or sodium nitrite at a dose which exerted beneficial effects on the progression of PH. In line with our results, Mathew et al. [13] demonstrated that the long-acting NO donor mo
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Toc and Toc are GTPases that regulate initial
2021-09-29
Toc34 and Toc159 are GTPases that regulate initial steps of preprotein import [3,4,26]. It was shown that GTP hydrolysis of at least one receptor is necessary to initiate the translocation process [23,27]. As reported for other small G-proteins, Toc34 and Toc159 bind their cargo in a nucleotide-depe
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Furthermore the higher expression levels of
2021-09-29
Furthermore, the higher expression levels of DNMT1 seemed to be responsible for the elevated levels of methylation in the GSTP1 and TXNRD2 promoters in HMC. In the DNA methyltransferase family, the functions of DNMT1 and DNMT3, including 3a and 3b, were the most ubiquitously expressed in cells. DNMT
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Glutathione in reduced form GSH the tripeptide glutamyl cyst
2021-09-29
Glutathione in reduced form (GSH, the tripeptide, γ-glutamyl cysteinyl glycine) is a non-enzymatic low-molecular-weight antioxidant necessary for the maintenance of a cellular redox state (Noctor et al., 2012). At the stage of the transition from germination to seedling growth the process of cell di
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adenosine receptor antagonist br Introduction br Mitochondri
2021-09-29
Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu
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