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PPM-18 receptor br Introduction The role of histamine in
2021-11-18
Introduction The role of histamine in allergic responses, anaphylaxis, and gastric PPM-18 receptor secretion has been well described in both human and veterinary medicine. New roles for histamine and its receptors, however, have been elucidated over the last two decades (Smuda and Bryce, 2011), a
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Stability of DBS over the day time
2021-11-18
Stability of DBS over the 60-day time points was encouraging, with a maximum of 0.1 log10 IU/mL degradation from the day 1 value (Supplementary Fig. 1 and Supplementary Table 3). Discussion This study evaluated the sensitivity and specificity of the Aptima HCV Dx assay for HCV RNA detection from
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We have shown previously that activation of the TGF Smad
2021-11-18
We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates T7 High Yield RNA Synthesis cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic
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The discovery that the physiological functions
2021-11-18
The discovery that the physiological functions of LPI are associated with the activation of specific GPR55 membrane receptor [4] has launched a new era of research on this lysophospholipid. However, the activation of membrane receptors by lysophospholipids is extremely complex due to the multitude o
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The rat model was validated with another agonist of GPR
2021-11-17
The rat model was validated with another agonist of GPR109A, acipimox. Acipimox has been shown to induce vasodilatation in man, by a mechanism dependent on the release of vasodilator prostaglandins (Edlund et al., 1990, Pontiroli et al., 1992). Acipimox is a weaker agonist of the GPR109A receptor (L
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Arctigenin There is sufficient evidence to indicate that kis
2021-11-17
There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH Arctigenin and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was cl
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The study of TcMYH protein is
2021-11-17
The study of TcMYH protein is a step forward for the characterization of a GO system in T. cruzi. The complete system appears to be present and our findings demonstrate that is important to maintain DNA stability of the nuclear and mitochondrial genomes, particularly in the presence of oxidative st
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br Acknowledgements This work was supported
2021-11-17
Acknowledgements This work was supported by grants from la Ligue Nationale Française Contre le Cancer « Equipe LNCC 2016 » and Electricité de France RB 2016-17 (to M.S.), NU ORAU (http://www.nu.edu.kz) and Ministry of Education and Science of the Republic of Kazakhstan, program 0115RK03029 (to B.
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br GSMs Secretase cleavage of APP generates
2021-11-17
GSMs γ-Secretase cleavage of APP generates a number of Aβ peptides [32], [137]. In most cells Aβ1–37, 38, 39, and 42 are produced at low levels (typically each represents 5–20% of total Aβ detected) and the major species generated is Aβ1–40 (typically over 50% of total Aβ). Other Aβ peptides can
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The C terminal regions in both FGF and FGF define
2021-11-17
The C-terminal regions in both FGF19 and FGF21 define their KLB interaction [15], [16], [23], [25]. However, less than 40% identity in comparative alignment of C-terminal sequences for these two proteins (Table 1) suggests that their interaction with KLB may require higher-order association with oth
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Aminophylline Free fatty acids FFAs which are
2021-11-17
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Aminophylline receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Shor
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In summary PPARG and FFAR are connected in
2021-11-17
In summary, PPARG and FFAR1 are connected in several ways, and the presented interaction is mechanistically reasonable. Additional investigations are required to elucidate the exact details of the underlying physiology. However, our findings are of immanent importance for the treatment of type 2 dia
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Apoptosis via Fas FasL system has been evidenced
2021-11-17
Apoptosis via Fas/FasL system has been evidenced to play a role in the pathogenesis of many diseases [26], [27], [28], [29], [30], [31], [32], [33], [34]. Along with these, Fas/FasL system has an important role in progressive renal disease and organ rejection in renal, cardiac and liver transplanta
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The even bigger surprise was the second feature
2021-11-17
The even bigger surprise was the second feature of both structures. Interestingly, binding of the MRG domain hardly altered the conformation of the SET domain compared with its apo state (An et al., 2011). What did change, however, is the conformation of the ASH1L auto-inhibitory loop (Figure 1). De
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BMP signals play pivotal roles
2021-11-17
BMP signals play pivotal roles in the various processes of chondrogenesis [12], [13]. At early stages of chondrogenesis, BMP signaling regulates the differentiation of mesenchymal Estradiol 17-(β-D-Glucuronide) sodium salt into chondrocytes via the induction of Sox9[29]. The loss of Noggin, a BMP a
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