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BIO-acetoxime A repertoire of cytotoxic payloads is increasi
2021-12-20
A repertoire of cytotoxic payloads is increasing; among those, MMAE has been utilized for the highly effective ADC brentuximab vedotin. However, the ADCs which utilized MMAE to target GCC in solid tumors have shown a poor efficacy suggesting that various tumor types respond differently to a given to
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Introduction Glycogen synthase kinase GSK is
2021-12-20
Introduction Glycogen synthase kinase-3 (GSK-3) is an enzyme playing multiple roles in animal tissues and organs, and regadenoson is not an exception. Apart from involvement in regulation of apoptosis and survival GSK-3 influences neuronal morphology, synapse formation, memory reconsolidation in a
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Using RT PCR we demonstrated the expression of GPR
2021-12-20
Using RT-PCR we demonstrated the expression of GPR55 receptor mRNA in the ileum and colon of mice, which is in good agreement with previous reports (Lin et al., 2011). The quantitative analysis showed the abundance of GPR55 mRNA in the mucosa of the ileum and colon. In contrast, in LMMP preparations
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br Activity dependent control of myelination and myelin
2021-12-20
Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed 76 7 synthesis in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or other cells
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So far GnRH receptors have been detected in
2021-12-20
So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa SKF 81297 hydrobromide mg of pre-ovulatory follicles, but not of follicles from the
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Obestatin synthetized mainly in the gastrointestinal tract p
2021-12-20
Obestatin, synthetized mainly in the gastrointestinal tract, participates in the regulation of metabolic functioning at both central and peripheral levels (food intake, pancreatic activity or/and adipocytes proliferation) (Granata et al., 2008; Li et al., 2011). It is involved in the complex gut-bra
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In the absence of HH ligand HH signaling is actively
2021-12-20
In the absence of HH ligand, HH signaling is actively maintained in a repressed state by the activity of the HH receptor Patched (PTCH). PTCH is a 12-transmembrane domain protein whose intracellular localization is concentrated at the our site of the primary cilium, a single antenna-like structure
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The differences in metabolites fermentation characteristics
2021-12-20
The differences in metabolites, fermentation characteristics in skim milk, and the use of lactose revealed by principal component analysis are shown in Figure 3C. Notably, D-XJ4–12 appeared to be isolated from the rest of the strains mainly due to its lack of ability to use lactose. Lactococcus lact
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br PEPCK This enzyme decarboxylates and then phosphorylates
2021-12-20
PEPCK This enzyme decarboxylates and then phosphorylates oxaloacetate to form phosphoenolpyruvate (PEP) in the second step of gluconeogenesis after the carboxylation of pyruvate catalyzed by PC. PEPCK1 (PEPCK-C, encoded by the PCK1 gene) and PEPCK2 (PEPCK-M, encoded by the PCK2 gene) are two isof
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br Conflicts of interest br Acknowledgments This work
2021-12-20
Conflicts of interest Acknowledgments This work was supported by the Project of Huzhou Municipal Science and Technology Bureau of Zhejiang Province (No. 2016GY45 to YGC) and he Project of Zhejiang Basic Public Benefit research of Zhejiang Province (No. LGF18H160005 to YGC) Introduction Wit
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br Conclusions and perspectives br Acknowledgements This wor
2021-12-20
Conclusions and perspectives Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant Nos. 21802173, 21405182 and 21773315), the Natural Science Foundation of Guangdong Province (Grant Nos. 2018A030310301, 201710010019 and 2014A030313232, 201804020025
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Hyperhomocysteinemia HHcy is a clinical condition characteri
2021-12-20
Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino LY2228820 formed during the intracellular conversion of methionine to cysteine. Previous study demons
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The lower number of samples
2021-12-20
The lower number of samples tested for the comparison between cobas 4800 HIV-1 and RealTime HIV-1, especially at or below 50 copies/mL (Table 6), could limit our ability to discern a difference in the ability of the various assays to identify patients with virological failure. However, the 95% CI ar
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While phosphorylation site motifs are typically described in
2021-12-18
While 10-Hydroxycamptothecin site motifs are typically described in terms of residues that promote phosphorylation, negatively selected residues can also be an important component of substrate recognition. Such ‘forbidden’ resides can act as a filter to prevent phosphorylation of a site by the ‘wro
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br Material and methods br Results and
2021-12-18
Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of Vincristine sulfate australia biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, ar
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