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br Materials and methods br Results
2022-01-03
Materials and methods Results Discussion D. abbreviatus larvae are voracious feeders, and the nutrients consumed as part of their diet are broken by gut proteases and utilized for growth and development. Since proteases play an important role in larval and adult food digestion, it is import
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br Intracellular trafficking with concurrent signaling of NP
2022-01-03
Intracellular trafficking with concurrent signaling of NPRA Our recent studies have shown internalization and concurrent signaling of NPRA in subcellular compartments; this had not been previously demonstrated [26,42]. Preparation of the enhanced GFP (eGFP)-tagged NPRA (eGFP-NPRA) construct has g
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BI 6015 Acute in vivo experiments were performed in
2022-01-03
Acute in vivo experiments were performed in normoglycemic 129SVE mice to confirm GPR119 activation and corresponding BI 6015 control. GIP release was utilized as a biomarker for target receptor engagement and plasma GIP levels were measured 45min after oral dosing (). Both 3 and 10mg/kg produced an
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Consistent with these observations impaired transduction of
2022-01-03
Consistent with these observations, impaired transduction of the glutamate signal by NMDARs (i.e., NMDA receptor hypofunction [NRH]) by parvalbumin-containing GABAergic inhibitory interneurons is implicated in mediating social deficits, a domain of psychopathology responsible for poor functional out
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To further explain the energy differences between
2022-01-03
. To further explain the energy differences between Group-A and Group-B, the average distances between ligands and the zinc cation were obtained from the last 1ns trajectory. It turns out that the members of group A were within the coordination distance of the zinc ion, whereas those of group B stay
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The previous studies focused on the regulation of GK
2022-01-03
The previous studies focused on the regulation of GK activity by nutrients directly or nutritional hormones (Panserat et al., 2014), there was still a lack of studies paid attention to GK both in activity level and transcriptional level. Besides, the GK regulation by dietary PPADS tetrasodium salt r
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GK also called hexokinase IV or D is a
2022-01-03
GK, also called hexokinase IV or D, is a glycolytic enzyme that converts (-)-Huperzine A to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancreatic β-cells
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Ghsr may have therapeutic value in disorders
2022-01-03
Ghsr may have therapeutic value in disorders associated with impairments in AHN. As anxiety disorders and enhanced fear responses observed in PTSD are linked with overgeneralization of similar but distinct memories (i.e poor discrimination), we suggest that acyl-ghrelin’s anti-anxiety effect (Lutter
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br Material and methods br Results br
2022-01-03
Material and methods Results Discussion Propofol is commonly used in operation rooms or intensive care units (ICUs) for critically ill patients. Various clinical trials have demonstrated that the antioxidant, anti-inflammatory, and free-radical-scavenging properties of propofol can provide
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However Gingrich and Hen reported that absence of the gene
2022-01-03
However, Gingrich and Hen reported that absence of the gene at all stages of ontogenesis of mice may interfere with the normal developmental program and/or the organism may undergo changes in other systems to compensate for gene absence (46). In addition, potentially altered maternal behavior of GPR
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Cy5 maleimide (non-sulfonated) A second site of histone core
2022-01-03
A second site of histone core domain acetylation that that has been observed on newly synthesized histones is histone H4 lysine 91 [34]. H4 lysine 91 lies along the interface between the H3/H4 tetramer and the H2A/H2B dimers. In fact, H4 lysine 91 normally forms a salt bridge with an aspartic Cy5 ma
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To identify genes with significant expression differences we
2022-01-03
To identify genes with significant Doxycycline HCl differences, we performed differential gene expression analysis between the two individuals with TRRAP variants (combined as biological replicates) and two unaffected controls. Gene ontology (GO) enrichment analysis of these genes with the GOrilla w
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In this study there is a limitation in
2022-01-03
In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual FITC, Fluorescein isothiocyanate emptying was needed until reflex bladder emptying was established (Lu et al., 2008,
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On the other hand after injury of
2022-01-03
On the other hand, after injury of the adult heart, inflammatory monocytes are abundantly recruited to damaged myocardium and they differentiate into monocyte-derived macrophages (MDMs). They have strong proinflammatory phenotype and very limited capacity to promote angiogenesis and cardiomyocyte pr
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N6022 br Acknowledgments br Introduction Liver disease is
2022-01-03
Acknowledgments Introduction Liver disease is one of the leading causes of death worldwide. Death from any type of acute or chronic liver injury results when sufficient healthy hepatic parenchyma cannot be regenerated to perform vital liver-specific functions. Although the regenerative capabil
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