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br Conclusion The mitochondrial and glycolytic
2022-03-26
Conclusion The mitochondrial and glycolytic energy metabolism of the brain is coordinated by HKI binding to MOM, although the molecular mechanism of such a regulation is not yet clear. The natural aromatase inhibitors for HKI in MOM are VDACs [[5], [6], [7]], mainly the VDAC1 isoform [8]. Using
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Sonidegib is currently under investigation for the
2022-03-26
Sonidegib is currently under investigation for the treatment of relapsed/refractory acute leukemia (NCT01826214) [76]. All patients experienced at least 1 AE, including anemia, diarrhea, fatigue, nausea, muscle spasms, decreased appetite, and blood creatine phosphokinase increased. The ongoing phas
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Currently the computational chemical biology has been applie
2022-03-26
Currently, the computational chemical biology has been applied in hepatitis B antiviral drug discovery research [18]. Tan et al. explored oxime ethers as HBV inhibitors by docking and screening [19]. Allen et al. clarified the resistance of HBV to the nucleoside drug lamivudine [20]. The results sug
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br Intracellular trafficking with concurrent signaling of NP
2022-03-26
Intracellular trafficking with concurrent signaling of NPRA Our recent studies have shown internalization and concurrent signaling of NPRA in subcellular compartments; this had not been previously demonstrated [26,42]. Preparation of the enhanced GFP (eGFP)-tagged NPRA (eGFP-NPRA) construct has g
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Typically upon chronic agonist exposure GPCRs undergo
2022-03-25
Typically, upon chronic agonist exposure GPCRs undergo desensitization and internalization resulting in a loss of receptor responsiveness over time (Drake et al., 2006, Kelly et al., 2008). However, not all GPCR systems conform to this model of acute agonist-mediated regulation. Some receptors have
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There is sufficient evidence to indicate that kisspeptin pla
2022-03-25
There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH bcl2 and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was cloned,
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Another group of secreted proteins
2022-03-25
Another group of secreted proteins that determine the virulence of V. dahliae are effectors and microbe associated molecular patterns (MAMP) that regulate plant immunity [10]. So far, there is only one 3MB-PP1 gene Ave1 cloned in V. dahliae, yet it does not exist in race 2 strains such as V592 and
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br Recent insights into EAAT structure function aspects The
2022-03-25
Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen
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br Discussion The present study
2022-03-25
Discussion The present study showed that glutamate transporter the factors of pre-exposure and glutamate drug injections might affect the total latency time. However, the factor of sex did not affect the total latency time. The results indicate that the glutamate system and pre-exposure, but not
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To study the effects of GPR at
2022-03-25
To study the effects of GPR40 at the whole-animal level, GPR40 mice have been generated in two different genetic backgrounds [18], [19]. GPR40 mice from both backgrounds were apparently healthy with no overt signs of metabolic or other abnormalities. As expected, pancreatic islets taken from GPR40 m
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Taking into account abovementioned vitamin
2022-03-25
Taking into account abovementioned, vitamin D3 deficiency effects on synaptic neurotransmission can be considered as targeting both Ca2+-independent and Ca2+-dependent processes. Ca2+-independent action of vitamin D3 deficiency is associated with a decrease in the expression of glutamate and GABA tr
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To confirm the in vitro findings atorvastatin or
2022-03-25
To confirm the in vitro findings, atorvastatin or pravastatin was given to C57BL6/J mice fed with high fat diet. Doses of atorvastatin were set to be 6 mg/kg and 12 mg/kg, which were within clinical therapeutic doses. The results revealed that treatment of atorvastatin but not pravastatin impaired g
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br Materials and methods br Results br
2022-03-25
Materials and methods Results Discussion Common to catfish fry production, high stocking densities as well as intensive handling during transport can result in low dissolved oxygen levels (Abdalla and Romaire, 1996; Torrans et al., 2003), which can result in fish stress. It is not known at
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Herein in consider of the
2022-03-25
Herein, in consider of the high similarity between GR HBP site and AR HBP site, we applied rational drug design strategy to develop AR/GR antagonists based on the chemical structures of antiandrogens and crystal structure of GR. The following bioassay identified Z19 as a dual AR/GR antagonist. Z19 i
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The differences in metabolites fermentation
2022-03-25
The differences in metabolites, fermentation characteristics in skim milk, and the use of lactose revealed by principal component analysis are shown in Figure 3C. Notably, D-XJ4–12 appeared to be isolated from the rest of the strains mainly due to its lack of ability to use lactose. Lactococcus lact
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