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It is interesting to note that the
2022-08-05
It is interesting to note that the long and short forms of GPR120 exist at different basal levels of phosphorylation, with the short form demonstrating a greater degree of constitutive activity [12]. Importantly, Burns and Moniri [12] showed that, upon activation, the long and short isoforms of GPR1
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br Experimental br Acknowledgments The authors are grateful
2022-08-05
Experimental Acknowledgments The authors are grateful to Fundamental Scientific Research Fund of Chinese Academy of Medical Sciences (No. 2016ZX350030) for financial support. Introduction 2-Lysophosphatidylcholines (1-acyl-glycero-3-phosphocholines, 2-LPC) are blood derived factors involve
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EMD-1214063 Hepcidin expression was not affected under GlyT
2022-08-05
Hepcidin expression was not affected under GlyT1 inhibition. Hepcidin downregulation is well documented in conditions of ineffective erythropoiesis and dyserythropoietic anemias, including sideroblastic anemia 33, 34. Systemic iron acquisition under these types of anemia is obviously independent fro
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br Materials and methods E coli strains Strains of
2022-08-05
Materials and methods E. coli strains. Strains of E. coli with mutations in the lacZ gene for β-galactosidase [5] and a derivative with a knock-out mutation of the chromosomal gene for FPG produced with P1vir [6] were obtained from H. Schellhorn (McMaster Univ., Hamilton, Ontario, Canada). Growth
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Resolving the molecular details of glyco
2022-08-05
Resolving the molecular details of (glyco)proteome variation in different tissues and organs of the human body is critical for the understanding of human biology and disease [59]. Glycoproteomic analysis of disease-related tissues and cells has provided valuable information to identify promising tar
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br Introduction The generic antifibrinolytic drug
2022-08-05
Introduction The generic antifibrinolytic drug tranexamic KX2-391 dihydrochloride (TXA) inhibits the protein-protein interaction between plasminogen and fibrin [9]. TXA is frequently used to reduce bleeding in various hemorrhagic conditions, such as during surgical procedures in the heart [19].
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To examine the possible role of
2022-08-05
To examine the possible role of mGluRs in the LH/PFA in the hypercapnic ventilatory response, a nonspecific antagonist of mGluRs, MCPG, was microinjected into the LH/PFA. MCPG elicited a significantly increased hypercapnic ventilatory response in awake rats, but not during sleep, in the light and da
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br Experimental section br Introduction Fasting hyperglycaem
2022-08-05
Experimental section Introduction Fasting hyperglycaemia in all forms of diabetes mellitus occurs primarily as a result of upsurge in hepatic glucose synthesis (HGS) [1], [2]. Two specific enzymes, glucokinase (GK) and glucose-6 phosphatase (Glu-6-Pase) play crucial role in hepatic glucose pro
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In this study an galactosidase gene GalA from
2022-08-05
In this study, an α-galactosidase gene, GalA, from a Aspergillus oryzae strain RIB40 [14] was artificially synthesized. To produce high levels of secretory expression in Pichia and facilitate its industrial application, we systematically investigated the gene dosages and the role of the ERSAs, namel
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br Materials and methods br Results and discussion br Conclu
2022-08-05
Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm
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SKF38393 HCl Recently some researchers working in China Phar
2022-08-04
Recently, some researchers working in China Pharmaceutical University developed novel FFA1 agonists some of which were found to be efficacious in the management of type 2 diabetes and with low toxicity. For instance, Zheng et al. [48] in their in vivo study using experimental animals, reported that
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br Methods and materials br
2022-08-04
Methods and materials Conflict of interest statement Introduction Ferroptosis (ferro = “ferrous ion (Fe2+)”, ptosis = “fall”), implicating the crucial role of cellular iron played in cell death, is a new form of nonapoptotic programmed cell death characterized by iron-dependent accumulation
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We have expanded these studies by doing EEG
2022-08-04
We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA ONO-8711 sale or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antago
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CJ-42794 br Results br Discussion In this study
2022-08-04
Results Discussion In this study, six new T30695 variants were synthesized with the acyclic R or S glycerol linker instead of CJ-42794 unit at 4, 8 or 12 T residue. Based on our previous studies on TBA-GQ, this type of modification should provoke local changes in GQ conformations in the final
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Previous studies have attributed the changes
2022-08-04
Previous studies have attributed the changes that occurs during the behvioral sensitization to many psychostimulants with neuroadaptation in dopaminergic cell bodies of the VTA (induction phase) along with alteration in dopamine axon terminal field transmission of NAc during the expression to sensit
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