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The ability of GPX and other selenoproteins to be
2022-09-21
The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face
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The investigation in vitro revealed that
2022-09-21
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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The conjugated gold is an essential part of rapid test
2022-09-20
The conjugated gold is an essential part of rapid test kits. For this PIs-IC strip the gold nanoparticles were conjugated with an optimal concentration of antibody to produce a stable nanoparticle solution (Fig. 3). From TEM images it became obvious that the colloid gold contained particles of diffe
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br Introduction Glycolysis plays a key role in brain
2022-09-20
Introduction Glycolysis plays a key role in Dynorphin A mg energy metabolism [[1], [2], [3]]. It is initiated mainly by hexokinase I (HKI), the major hexokinase isoform of the brain ([3,4] and references therein). Up to 90% of brain HKI is bound to the mitochondrial outer membrane (MOM) through t
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Interestingly interactions between Smad and RhoA the other
2022-09-20
Interestingly, interactions between Smad3 and RhoA, the other small GTPase which is highly homologous to RhoB [9], could not be observed suggesting that the Smad3/RhoB interactions require amino ER 27319 maleate residues that are unique to RhoB. Combined with our previous observation that the RhoA g
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SBI-0206965 synthesis Given the involvement of dysregulated
2022-09-20
Given the involvement of dysregulated S-nitrosylation in multiple pathological conditions, a number of approaches to regulate S-nitrosylation therapeutically are being tried in multiple indications [18]. In the lung, GSNO releasing compounds and GSNOR inhibitors are being considered as potential the
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br Author contributions br Conflict of
2022-09-20
Author contributions Conflict of interest Acknowledgments We appreciate technical support of the Research Support Center at the Graduate School of Medical Sciences of the Kyushu University. This study was supported by the Uehara Memorial Foundation and a KAKENHI grant from the Ministry of E
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Molecular mechanisms of decidualization have been studied fo
2022-09-20
Molecular mechanisms of decidualization have been studied for years, revealing numerous signaling pathways and transcriptional factors participated in the regulation [37,38]. As a central controller of deicdualization, FOXO1 regulates the transcription of a large number of target genes, which are in
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On the other hand we
2022-09-19
On the other hand, we have previously demonstrated that gelsemine displaced the H3-strychnine from membrane fractions of rat spinal cord homogenates. In addition, spinal gelsemine antinociception was blocked by intrathecal injection of the specific glycine receptor antagonist strychnine or gene sile
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A key limiting factor in the semi quantitative analysis
2022-09-17
A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Cryptotanshinone of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This
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Ghrelin receptors in non mammals are reportedly
2022-09-17
Ghrelin receptors in non-mammals are reportedly more “complicated/complex and diverse” than in mammals, having additional paralogs and splice variants (Kaiya et al., 2014). Several teleost fish GHS-Rs have been identified; however, functional characterization has been conducted in only a few (see, K
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Albumin is the major carrier of free fatty acids FFAs
2022-09-17
Albumin is the major carrier of free fatty acids (FFAs) in plasma [59], and harbours seven binding sites that are common to FFAs with a range of chain-lengths (C10-C18) across its three domains (Fig. 1a) [60,61]. In vitro, saturated, mono- and poly-unsaturated FFAs, with chain lengths ranging from C
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Bindarit Here we investigated on epigenetic regulatory mecha
2022-09-17
Here, we investigated on epigenetic regulatory mechanisms of ALX/FPR2 expression. Epigenetic changes, that include phosphorylation, acetylation, methylation and ubiquitination of DNA and histone proteins, occur in a variety of diseases [21] and are being recognized as key targets for personalized me
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br Clinical development of FGFR
2022-09-17
Clinical development of FGFR inhibitors in breast cancer The rationale to explore the role of FGFR inhibitors in patients with breast cancer comes from a variety of sources. These include genomic aberrations frequently identified in the FGF/FGFR pathway in breast cancer, the increased sensitivity
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Glucose metabolic pathways are well defined but the
2022-09-17
Glucose metabolic pathways are well defined but the subcellular organization of these pathways is poorly understood in liver and kidney. Several factors affect the net flux of gluconeogenesis and allow the MPEP Hydrochloride to respond to physiological changes [1]. Ovadi and Srere have suggested th
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