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In summary we identified a novel MLPH ALK fusion
2023-03-29
In summary, we identified a novel MLPH-ALK fusion in AST with discordant results of ALK IHC. In order not to overlook ALK-rearranged AST with rare fusion partners on IHC screening, a sensitive IHC method is preferable. Introduction Lung cancer remains the leading cause of cancer related deaths w
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br ABCA mRNA expression is elevated in Niemann
2023-03-28
ABCA2 mRNA expression is elevated in Niemann-Pick type C and familial hypercholesterolemia fibroblasts Niemann-Pick Type C disease is a neurological disorder of adolescents due to autosomal-recessive mutations in either one or both Niemann-Pick-2 (NPC2) and NPC1 genes, which, like ABCA2, are loca
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GDC-0199 PGR regulation of epithelium stroma crosstalk is pr
2023-03-27
PGR regulation of epithelium–stroma crosstalk is proven by numerous studies that utilize genetically engineered mouse models. Before embryo implantation, epithelial PGR mediates the progesterone signal to transcriptionally increase the Ihh levels 13, 15. Epithelial IHH then activates the stromal hed
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The functions of HMGN protein are
2023-03-25
The functions of HMGN1 protein are modulated by various post-translational modifications, including phosphorylation , , , acetylation , and glycosylation . Phosphorylation in HMGN1 may influence its binding affinity to DNA or nucleosome-associated proteins and affect the sub-cellular localization an
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Women are usually at risk of
2023-03-22
Women are usually at risk of sleep deprivation or restriction during pregnancy, especially in the third trimester of gestation, due to the pregnancy-associated anatomic, physiological and hormonal changes (Pien and Schwab, 2004). However, several major Pefloxacin developmental events, such as the n
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br Materials and met http
2023-03-22
Materials and methods Results The values for body weight are shown in Fig. 1. Body weight was measured every day. The body weight of the young mice in the control (i.e. no-stress) group was not significantly different from that of the young mice in the stress group. However, the middle-aged mi
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br Materials and methods br Results br Discussion In the
2023-03-22
Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi
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Within the PARP family TIPARP is
2023-03-22
Within the PARP family, TIPARP is most evolutionarily conserved with PARP12 (ARTD12) and PARP13 (ARTD13) [27,28,41]. All three proteins contain at least one RNA-type CCCH zinc finger domain, a poly-ADP-ribose binding WWE domain and a PARP catalytic domain (Fig. 1). PARP13 is catalytically inactive,
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Implicit in this concept is the idea that the
2023-03-22
Implicit in this concept is the idea that the β-adrenoceptors in the detrusor would be activated by adrenergic nerves of the sympathetic system: sympathetic activity promoting relaxation and enhancing bladder capacity. However, it has been demonstrated that there is only a sparse adrenergic innervat
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Some of the studies reported elevated ADA levels in
2023-03-22
Some of the studies reported elevated ADA levels in schizophrenia patients (SZ) undergoing treatment with antipsychotics (Dutra et al., 2010; Brunstein et al., 2007; Ghaleiha et al., 2011). However, it is unclear whether the increased serum ADA reported in these studies was the consequence of treatm
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br GMF Remodels Actin Networks
2023-03-22
GMF Remodels Actin Networks at the Leading Edge How are the conserved activities of GMF used in vivo to regulate branched omadacycline networks (e.g., at sites of endocytosis and at the leading edge) (Figure 2A,B)? In animal cells, the regulatory effects of GMF on actin networks appear to govern
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Luciferase Immunoprecipitation Systems LIPS which utilizes r
2023-03-22
Luciferase Immunoprecipitation Systems (LIPS), which utilizes recombinant antigens fused to the enzyme reporter Renilla luciferase (Ruc) to detect patient antibodies, provides a unique platform to investigate 95531 receptor directed against a variety of antigenic targets [25]. Previously, LIPS has
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br Conflict of interest statement br Benign prostatic hyperp
2023-03-22
Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal Calphostin C in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular
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Direct inhibition of LO activity by BRP is clearly evident
2023-03-22
Direct inhibition of 5-LO activity by BRP-187 is clearly evident in cell-free assays using PMNL homogenates and isolated human recombinant 5-LO as enzyme source. In such assays, pure FLAP inhibitors like MK886 are inactive [9], [10], [29], [44]. Wash-out experiments and studies using the nonionic de
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The H N mutation in exon has not previously
2023-03-22
The H373N mutation in exon 6 has not previously been reported [3], [4], [5], [6]; thus, this mutation appears to be a novel mutation. The functional expression study demonstrated that the H373N mutation results in almost complete loss of enzymatic activity. Thus, it is highly likely that the H373N m
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