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br Acknowledgements This work was supported
2023-09-22
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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br Introduction Myasthenia gravis MG is an autoimmune
2023-09-22
Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against l-ascorbic acid receptor (AChR) [1]. In AChR negative MG patien
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br Trauma and ACEs screening the past present and
2023-09-22
Trauma and ACEs screening: the past, present, and future Traditionally, allopathy’s biomedical model has utilized an etic perspective; the outsiders’ view of the problem. Development of diagnostic screening tools requires an etic approach, which relies heavily on a completely objective perspectiv
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rs G allele was previously associated with a decrease
2023-09-22
rs523349 G allele was previously associated with a decrease in the conversion rate of testosterone to DHT (Beesley et al., 2007). This SRDA52 variant may have a trend towards higher testosterone availability, which according to the US Food and Drug Administration is described as a teratogen of categ
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Receptor tyrosine kinase Axl is
2023-09-22
Receptor tyrosine kinase Axl is a member of the TAM (Tyro3/Axl/Mer) family, and has reported been associated with a spectrum of human cancers [8]. Numerous studies have revealed that the oncogenic potential of Axl is attributed to the anti-apoptotic and proliferative signaling pathways triggered by
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PF also a dual Aurora A
2023-09-22
PF-03814735, also a dual Aurora-A and Aurora-B inhibitor, was administered in a phase I dose escalation study in a 3-weekly Irinotecan HCl Trihydrate for 5 or 10 consecutive days [69], [70]. To date 25 patients have been included in 7 dose levels (5–100mg/day for 5 days). Using the 5-day schedule t
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As shown in B the recombinant
2023-09-22
As shown in B, the recombinant human 15-LOX-1 (30nM) showed a time-dependent increase in fluorescent signal, and signal development was almost completed within 20min in the presence of 50μM arachidonic glasdegib and 5μM DHR. For both purified enzyme and cell lysates, the enzyme activities disappeare
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Because ASK signaling in microglia
2023-09-22
Because ASK1 signaling in microglia and astrocytes is important during EAE, we hypothesized that a combination therapy that targets T cells along with microglia and astrocytes would further ameliorate the severity of EAE. We tested this hypothesis by applying valproic Bupivacaine HCl (VPA)—a short-
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hippo pathway There are essentially two screening strategies
2023-09-22
There are essentially two screening strategies to minimize the number of newborns recalled for additional testing without missing cases for most screening disorders. For hyperargininemia, one strategy uses Arg alone as the indicator of possible disease and the other uses Arg in combination with a ra
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Plant defensins Vriens et al and
2023-09-22
Plant defensins (Vriens et al., 2014) and linear AMPs (Domingues et al., 2015, Liu et al., 2008) have been shown to present several modes of action. Among these different mechanisms, permeabilization of the fungal membrane has been described as a secondary effect of plant defensin action (Vriens et
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During the course of angiogenesis the overactivated
2023-09-22
During the course of angiogenesis, the overactivated angiogenic stimulators are responsible for carrying out abnormal proliferation in the retinal microvasculature, resulting in the formation of various immature blood vessels. These newly formed blood vessels become the prime spots for leakage of th
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In our sequential model for tau and
2023-09-22
In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal istradefylline in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in th
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br Conclusion These studies broadly demonstrate that dopamin
2023-09-22
Conclusion These studies broadly demonstrate that dopamine and endocannabinoid signaling in the NAc can have diverse effects on AMPAR-mediated synaptic function depending on previous psychostimulant experience. Here, we examined mechanisms underlying the depotentiation of AMPAR-mediated synaptic
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Inflammatory factors released by activated cells during AD a
2023-09-22
Inflammatory factors released by activated cells during AD are very important for the disease progression. Not only several inflammatory cytokines, such as IL-1β, IL-18, and IL-33, but also anti-inflammatory ones, as IL-10 and IL-13, are upregulated in the brain of AD patients (Morimoto et al., 2011
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isoxazole In contrast to the beneficial treatment of skin in
2023-09-21
In contrast to the beneficial treatment of skin-inflammation with PAH containing coal tar, epidemiology showed that environmental pollution, containing AHR-activating PAH, lead to more eczema [80]. Of note, other epidemiological data suggested that Th17 cell polarization may be enhanced air pollutio
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