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br Materials and methods br Results
2025-01-18
Materials and methods Results and discussions Conclusion Fermented camel milk with NS4 exhibited remarkable ACE-inhibitory activity, which revealed its potential application for the preparation of fermented camel milk beverage or fermented camel milk derived peptides in different foods or i
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br Diabetes and obesity fit
2025-01-18
Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased PDE5 inhibitor production, rise in adiposity, and an incr
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To maintain ATP levels postmortem muscle mobilizes its glyco
2025-01-18
To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield polyphenolic compound 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (Pinitiation of the experiment. We expected that if myosin ATPase is
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Researchers demonstrated that mitochondria are the main
2025-01-18
Researchers demonstrated that mitochondria are the main producers of ROS and are the most sensitive to the effects of ROS. Mitochondria-mediated apoptosis may not be limited to the role of cytochrome c in the activation of caspase-3 and ROS may provide an alternate mitochondrial signaling pathway (H
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In addition understanding the relationship between
2025-01-18
In addition, understanding the relationship between human metabolic processes and dietary antioxidant intake would provide opportunities for altering the diet to improve health (Prior, 2015). Prior et al. (2007) emphasized that excess reactive oxygen species, which occurred during the metabolism of
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We report here the first
2025-01-18
We report here the first study on the inhibitory effects of the organic nitrates – on human erythrocyte GR. The previous reports by Becker et al., investigated other nitro derivatives (including arylizoalloxazines) by using Beutler’s method, monitoring GR inhibition. Data of show inhibition of hGR
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Thus far a tight coupling has been
2025-01-18
Thus far, a tight coupling has been observed between mAbs that target aggregated Aβ and the occurrence of ARIA. If ARIA-E is caused by increased trafficking to and clearance of fibrillar Aβ from cerebral vessels (20), mAbs could be designed with conformationally specific epitopes selective for solub
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br Introduction It is well known that when epithelial cells
2025-01-18
Introduction It is well known that when epithelial cells are deprived of anchorage, they undergo detachment-induced apoptosis, also known as anoikis. Cancer cells, by contrast, are able to suppress anoikis and survive under anchorage -independent conditions in the circulating system, which is tho
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Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A
2025-01-17
Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in
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Our previous study revealed expression of AhR
2025-01-17
Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct notch signaling pathway (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorod
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br Conclusions Triptans are HT
2025-01-17
Conclusions Triptans are 5-HT1B/1D/(1F) receptors agonists and are considered as the gold standard for acute migraine treatment that have been proven effective. Unfortunately, they are contraindicated in patients with cardiovascular diseases due to their vasoconstrictor (side) effects (MaassenVan
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Cofilin is an additional actin severing protein present in s
2025-01-17
Cofilin is an additional dabigatran etexilate mesylate severing protein present in sperm cells that undergo phosphorylation/inactivation on serine 3 by Lim kinases (LIMK) and by Tes kinases (TESK) [48]. LIMK can be activated by several pathways, including one through the Rho/ROCK/LIMK cascade [49],
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etifoxine The cytoplasmic domain of muscle
2025-01-17
The cytoplasmic domain of muscle AChR is not accessible to etifoxine in vivo. Theoretically, therapy with the cytoplasmic domains should be safe. Safety is demonstrated by the facts that: (1) rats repeatedly immunized with the cytoplasmic domains in TiterMax adjuvant do not develop EAMG, although t
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Introduction Dementia is a common disease in the
2025-01-17
Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (
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Another important question concerns the
2025-01-17
Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi